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frameshift

noun

Etymology

From frame + shift.

  1. derived from *skey-✻ — “to cut, divide, separate, part”
  2. derived from *skeyb-✻ — “to separate, divide, part”
  3. inherited from *skiftijaną✻
  4. inherited from sċiftan — “to divide, separate into shares; appoint, ordain; arrange, organise”
  5. inherited from schiften
  6. inherited from schyft
  7. compounded as frameshift — “frame + shift”

Definitions

  1. A frameshift mutation.

  2. To use a starting point for translating a series of nucleotides that is off by an amount…

    To use a starting point for translating a series of nucleotides that is off by an amount not divisible by three, resulting in an entirely distinct set of codons.

    • Commonly, there are stimulatory signals in mRNA distinct from the shift site that greatly increase the level of frameshifting at the shift site.
    • Considering these costs, it seems likely that mechanisms may exist to stop frameshifted translation as soon as possible, depending on the frequency of occurrence.
    • Ribosomal frameshifting at a particular site can yield two protein products from one coding sequence or one protein product from two overlapping open reading frames.

The neighborhood

Vish — recursive loop

No curated loop yet for frameshift. Loops are being traced one word at a time while the ingestion pipeline matures.

sense glosses and etymology drawn from English Wiktionary · source · CC-BY-SA